Targeted treatment approaches in refractory germ cell tumors
نویسندگان
چکیده
منابع مشابه
Salvage chemotherapy for refractory germ cell tumors.
At the University of Southern California (USC), it is our practice to begin by estimating the likelihood of a durable remission based on individual characteristics. Factors including pure seminoma, prior complete response (CR) to cisplatin therapy, low-volume metastases, and a testicular primary predict for cure with standard-dose salvage[1-4] and may help clinicians identify patients for whom ...
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markers were measured every 6 weeks, and computed tomography (CT) scans of the chest, abdomen, and pelvis were evaluated every 12 weeks. CT or magnetic resonance imaging studies of the brain and bone scans were carried out where clinically indicated. 1 patient with teratocarcinoma achieved partial remission in the lungs and retroperitoneal lymph nodes as well as a decrease in alpha-fetoprotein ...
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Testicular cancer is considered a malignancy with a high cure rate even in patients with metastatic disease. Treatment strategies are based on the extent of the disease and prognostic factors and require cooperation of medical specialists such as medical oncologists, radiation oncologists and urologic surgeons. Today, cure rates of 95–99% for patients with early stage testicular cancer and 50–9...
متن کاملIntracranial germ cell tumors.
Intracranial germ cell tumors are a heterogeneous group of lesions which occur in children and adults. Within the classification of intracranial germ cell tumors, there are a variety of different tumor types which carry different prognoses. The diagnosis of an intracranial germ cell tumor usually requires histological information, but a subgroup of tumors will secrete specific tumor markers, in...
متن کاملExtragonadal germ cell tumors.
Germ cell cancer is the most common malignancy in men aged 15–35 years; 5% of the malignant germ cell tumors are of extragonadal origin [1]. An extragonadal germ cell tumor (EGGCT) is by definition a germ cell neoplasm displaying one of the histologies associated with gonadal origin, but located outside of the gonads. This specific clinical entity was first described in the 19th century [2, 3]....
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ژورنال
عنوان ژورنال: Critical Reviews in Oncology/Hematology
سال: 2019
ISSN: 1040-8428
DOI: 10.1016/j.critrevonc.2019.09.005